期刊
LEUKEMIA & LYMPHOMA
卷 58, 期 12, 页码 2934-2938出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2017.1344845
关键词
RAGE; advanced glycation endproducts; multiple myeloma; saliva; oxidative stress
Multiple myeloma (MM) is a hematological cancer with underlying causes associated with increased oxidative stress. Through signaling of their receptor RAGE, advanced glycation endproducts (AGEs) are known to increase oxidative stress associated with malignant transformation. In the present study, we have demonstrated that the levels of these compounds are increased in the saliva of myeloma patients with bone lesions. This data may provide a potential marker for bone lesions in MM and a potential target for the treatment of myeloma by blocking the AGEs or their receptor.
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