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Is there a relationship between vitamin D nutritional status and metabolic syndrome in childhood acute lymphoblastic leukemia survivors? A PETALE study

期刊

CLINICAL NUTRITION ESPEN
卷 31, 期 -, 页码 28-32

出版社

ELSEVIER
DOI: 10.1016/j.clnesp.2019.03.006

关键词

Acute lymphoblastic leukemia; Vitamin D; 25-hydroxyvitamin D-3; Insulin resistance; Metabolic syndrome; Lipids

资金

  1. Institute of Cancer Research of the Canadian Institutes of Health Research
  2. C17 Council
  3. Canadian Cancer Society
  4. Cancer Research Society
  5. Garron Family Cancer Centre at the Hospital for Sick Children
  6. Ontario Institute for Cancer Research (OICR)
  7. Pediatric Oncology Group of Ontario [TCF 118694]

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Background: Treatment of childhood acute lymphoblastic leukemia (cALL) has reached unprecedented success leading to survival rates reaching 90%. This is regrettably linked to increased risk of developing long-term health-related sequels into early adulthood. Objective: This study aims at assessing the relationship between the vitamin D status and metabolic biomarkers in PETALE, a well-characterized cohort of cALL survivors. Results: We demonstrate that 15.9% of the study participants exhibited 3 or more metabolic syndrome (MetS) risk factors. We also show a direct relationship between s25OHD(3) and plasma HDL-Cholesterol concentrations in female but not male participants. Conclusion: Our data, from a metabolically well-described cohort, support a modest role for vitamin D in lipid metabolism in childhood leukemia survivors. The major outcome of this study is the strong association between HDL-Cholesterol concentration and s25OHD(3) only in female subjects, thereby conveying vitamin D a gender-specific cardio-protective effect. cALL survivors represent a population at higher risk for secondary diseases. For this reason thorough nutritional evaluation, including vitamin D should be part of the regular follow-up. (C) 2019 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.

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