期刊
JOURNAL OF CANCER
卷 10, 期 7, 页码 1622-1632出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.27780
关键词
dopamine receptor; autophagy; tumor immunity; ferroptosis
类别
资金
- National Key Research and Development Program of China [2016Y FC1306900]
- National Natural Science Foundation of China [81573508]
- Open Foundation of Innovative Platform in Colleges and University of Hunan Province of China [[2015] 54]
Dopamine receptors are belong to the family of G protein-coupled receptor. There are five types of dopamine receptor (DR), including DRD1, DRD2, DRD3, DRD4, and DRD5, which are divided into two major groups: the D1-like receptors (DRD1 and DRD5), and the D2-like receptors (DRD2, DRD3, and DRD4). Dopamine receptors are involved in all of the physiological functions of dopamine, including the autonomic movement, emotion, hormonal regulation, dopamine-induced immune effects, and tumor behavior, and so on. Increasing evidence shows that dopamine receptors are associated with the regulation of tumor behavior, such as tumor cell death, proliferation, invasion, and migration. Recently, some studies showed that dopamine receptors could regulate several ways of death of the tumor cell, including apoptosis, autophagy-induced death, and ferroptosis, which cannot only directly affect tumor behavior, but also limit tumor progress via activating tumor immunity. In this review, we focus mainly on the function of the dopamine receptor on Bio-behavior of tumor as a potential therapeutic target.
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