期刊
JOURNAL OF EVIDENCE-BASED INTEGRATIVE MEDICINE
卷 24, 期 -, 页码 1-12出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/2515690X19843832
关键词
diabetes mellitus; oxidative stress; antioxidant; Dacryodes edulis
The present study evaluated the antidiabetic and antioxidant potential of the methanolic extract/solvent fractions of the leaves of Dacryodes edulis using a streptozotocin (STZ)-induced diabetic Albino Wistar rat model. The fasting blood glucose/insulin levels and inhibition of alpha-amylase and alpha-glucosidase were determined. Antioxidant activity was assessed in vitro by 2,2-diphenyl-1-picrylhydrazyl, hydroxyl, superoxide scavenging, reducing power, and total antioxidant capacity assays and in vivo by monitoring catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activities and reduced glutathione (GSH) and malondialdehyde (MDA) levels. The aqueous-methanol fraction exhibited the highest and significant (P < .05) reduction in fasting blood glucose (FBG; 54.03%) with a concomitant inhibition of alpha-amylase and alpha-glucosidase activities. The ethyl acetate fraction also exhibited a significant (P < .05) reduction in FBG and an increase in insulin levels in the treated diabetic Wistar rats. A significantly (P < .05) higher reducing power and radical scavenging activity was observed in the aqueous-methanol and ethyl acetate fractions. The aqueous-methanol and ethyl acetate fractions also significantly (P < .05) reversed the alterations in oxidative stress markers (GSH, MDA, CAT, and SOD) observed in the diabetic control group. In conclusion, the study demonstrated that the methanol extract of Dacryodes edulis ameliorates hyperglycemia and the associated oxidative stress in STZ-induced diabetic Wistar rats. These observed activities are largely due to the compounds that partitions into the aqueous-methanol (55:45) solvent fraction. This provides scientific evidence for the use of this plant extract in folk medicine and also a baseline data for its further characterization. Further work should be carried out to characterize the aqueous-methanol solvent fractions for the active compounds.
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