期刊
SAGE OPEN MEDICAL CASE REPORTS
卷 7, 期 -, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/2050313X19847804
关键词
New daily persistent headache; headache; NDPH; TNF-alpha; tumor necrosis factor alpha; Venlafaxine; 5HT-2a; serotonin
New daily persistent headache is a continuous, unremitting headache, notorious for its unresponsiveness to aggressive medical interventions. The underlying pathophysiology of new daily persistent headache is poorly understood resulting in unending, chronic pain. However, a prior study identified elevated tumor necrosis factor alpha within the cerebral spinal fluid of new daily persistent headache patients. Herein, we report on a patient who suffered with headache for 6 years failing to respond to over 20 different medical treatments, but found drastic improvement and eventual resolution with Venlafaxine. This drug binds to the 5-HT2A receptor inhibiting tumor necrosis factor alpha signaling. Therefore, we hypothesize a chronic inflammatory mechanism driving new daily persistent headache pathology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据