期刊
LARYNGOSCOPE
卷 128, 期 7, 页码 1531-1536出版社
WILEY
DOI: 10.1002/lary.27045
关键词
Upper respiratory tract infection; olfactory disorders; gray matter; voxel-based morphometry; olfactory bulb; olfactory training
资金
- Else Kroner-Fresenius-Stiftung
- Deutsche Forschungsgemeinschaft [DFG HU441-18-1]
Objectives/Hypothesis: Olfactory dysfunction is thought to be associated with reduced gray matter (GM) volume in olfactory-related brain areas. The aim of this study was to determine GM structural changes within olfactory-related regions of the brain in patients with smell loss due to upper respiratory tract infection (URTI) before and after olfactory rehabilitation. Study: DesignProspective intervention case-control study. Methods: Magnetic resonance imaging structural brain images were collected from 30 patients with smell loss due to URTI and 31 controls. Patients exposed themselves to odors (olfactory training [OT]) over 12 weeks and then were rescanned. Olfactory testing was performed using the validated Sniffin' Sticks test. GM was investigated with voxel-based morphometry. Results: GM volumes were found to be reduced in the limbic system and thalamus among pretraining patients compared to controls; in patients, OT was associated with a significant increase of GM volume in these two regions. The GM volume within other olfactory-related regions was not different between patients and controls. In addition, no relevant difference between the GM volume pre- and post-OT was observed in primary olfactory-related regions. Conclusions: OT was associated with an increase in GM volume of the hippocampus and the thalamus, possibly pointing toward a strategy for more effective exploitation of olfactory signals based on a higher degree of attention toward odors and association of memories with olfactory input.
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