期刊
LANGMUIR
卷 34, 期 1, 页码 173-178出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.7b02562
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资金
- Research Center Program of IBS (Institute for Basic Science) through the National Research Foundation of Korea (NRF) [IBS-R008-D1]
- International S&T Cooperation Program of IBS (Institute for Basic Science) through the National Research Foundation of Korea (NRF) [2014K1B1A1073716]
- Basic Science Research Program of IBS (Institute for Basic Science) through the National Research Foundation of Korea (NRF) [2016R1E1A1A01941202, 2016R1A4A1010796]
Fluorescent Au nanocrystals (AuNCs)-silica hybrid nano-composite (FLASH) was synthesized by co-condensation of surface-modified AuNCs. Present FLASH nanocomposite exhibited four times the enhanced photoluminescence and photocatalytic activity compared to single nano-crystals. On the basis of these enhanced optical features, we successfully demonstrated in vitro fluorescence bioimaging of introduced FLASH to human cervical cancer cell line (HeLa). Beyond the confirmation of photocatalytic activity from the photodegradation of methylene blue as a model compound, the regional selective photodynamic therapy of HeLa cells under UV irradiation was also presented. Taken together the enhanced optical features and further potential in theranostic applications, we expect that the present FLASH can be a promising tool for nanobiotechnology field.
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