期刊
ANALYST
卷 144, 期 8, 页码 2736-2745出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8an02057d
关键词
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资金
- National Nature Science Foundation of China [21775113, 21575107, 21375097]
- Science Fund for the Creative Research Groups of NSFC [20921062]
- Large-scale Instrument and Equipment Sharing Foundation of Wuhan University [20181063]
A novel method by hyphenating chip-based array ion-imprinted monolithic microextraction with inductively coupled plasma mass spectrometry (ICP-MS) was proposed for the online analysis of trace Gd in biological samples in this work. The poly(-methacryloxypropyltrimethoxysilane@Gd3+-surface ion-imprinted polymer) [poly(-MAPS@Gd3+-SIIP)] monolithic capillary was prepared via in situ polymerization on the vinyl-modified surface of poly(-MAPS) using Eu3+ as the mimic template. The prepared ion-imprinted monolithic capillary possessed higher selectivity and adsorption capacity to Gd3+ than the non-imprinted monolithic capillary. Eight poly(-MAPS@Gd3+-SIIP) monolithic capillaries were embedded in the channels of a microfluidic chip to fabricate a chip-based array microextraction device. Factors affecting the selectivity of the prepared ion-imprinted monolithic capillary including imprinted time and the composition of the prepolymerization solution, and extraction conditions for the fabricated chip-based array ion-imprinted monolithic capillary microextraction platform were optimized. A sample throughput of 18 h(-1) was achieved along with a low detection limit of 1.27 ng L-1 for Gd3+. The proposed chip-based array poly(-MAPS@Gd3+-SIIP) monolithic microextraction-ICP-MS method was used for the analysis of trace Gd in human urine and serum, and the recovery for spiking experiments was in the range of 88.1-96.7%. The developed integrated analysis platform possesses good interference resistance, high automation, high sensitivity and low consumption of the sample/agent, which makes it very suitable for the analysis of trace elements in complicated biological samples.
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