期刊
CASE REPORTS IN ONCOLOGY
卷 12, 期 1, 页码 260-276出版社
KARGER
DOI: 10.1159/000498985
关键词
Cardiotoxicity; Immune checkpoint inhibitors; Myocarditis; Autoimmune; Cardio-oncology
类别
The development of immune checkpoint inhibitors (ICIs) has revolutionized the treatment of patients with advanced stage cancers. However, immune-related adverse events are frequently observed. Cardiac toxicity from ICI therapy can range from asymptomatic troponin-I elevations to conduction abnormalities of the heart and even fulminant myocarditis. Although rare, myocarditis is a potentially fatal adverse effect of ICI therapy. We present a series of five cases of ICI-related cardio-toxicity diagnosed and managed at Roswell Park Comprehensive Cancer Center along with a review of published case reports in the literature. Our series highlights the importance of high clinical suspicion, early diagnosis of myocarditis, and prompt initiation of immunosuppressive therapy. (C) 2019 The Author(s) Published by S. Karger AG, Basel
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