期刊
LANGENBECKS ARCHIVES OF SURGERY
卷 403, 期 2, 页码 245-253出版社
SPRINGER
DOI: 10.1007/s00423-017-1643-0
关键词
Esophageal squamous cell carcinoma; Visceral obesity; Lymphatic invasion; Lymph node metastasis; Response prediction
类别
资金
- Japan Society for the Promotion of Science (JSPS) [15K10122]
- Grants-in-Aid for Scientific Research [15K10122] Funding Source: KAKEN
Purpose Visceral obesity is considered to be associated not only with chronic systemic inflammation but also with aggressive cancer behavior. However, the implication of visceral obesity in patients with esophageal squamous cell carcinoma (ESCC) is unclear. Methods Computed tomography volumetry was performed in 364 patients who underwent esophagectomy for ESCC. We calculated the ratio of the visceral fat area to the subcutaneous fat area (VS ratio), which is a valuable parameter of visceral obesity. Then, the clinicopathological characteristics were compared between patients with low VS ratio and those with high VS ratio. Results Overall and disease-specific survivals of patients with high VS ratio were significantly worse than those with low VS ratio (P < 0.001 in both). Patients with high VS ratio had considerably more advanced pN factor, higher prevalence of lymphatic invasion, and more number of metastatic lymph nodes than those with low VS ratio (P = 0.044, < 0.001, and 0.006, respectively). Among patients who received preoperative treatment, high VS ratio correlated with poor response to preoperative treatment (P = 0.040). Conclusions Visceral obesity was associated with lymphatic invasiveness and poor response to preoperative treatment in patients with ESCC, which may negatively influence their prognosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据