期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 15, 期 4, 页码 726-737出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.30369
关键词
autophagy; follicular development; atresia; granulosa cells
资金
- Trans-gene Key Project of China [2018ZX08009-27B]
- National Natural Science Foundation [31501924]
- Hubei Technical Innovation Project [2017ABA134]
- Hubei Natural Science Foundation [2018CFA014]
- Innovation Team of the Hubei Agricultural Science and Technology Innovation Center [2016-620-000-001-022]
- Hubei Academy of Agricultural Sciences Youth Science Fund [2018NKYJJ09]
Autophagy is a mechanism that exists in all eukaryotes under a variety of physiological and pathological conditions. In the mammalian ovaries, less than 1% of follicles ovulate, whereas the remaining 99% undergo follicular atresia. Autophagy and apoptosis have been previously found to be involved in the regulation of both primordial follicular development as well as atresia. The relationship between autophagy, follicular development, and atresia have been summarized in this review with the aim to obtain a more comprehensive understanding of the role played by autophagy in follicular development and atresia.
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