期刊
LANCET NEUROLOGY
卷 16, 期 11, 页码 934-944出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S1474-4422(17)30329-0
关键词
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资金
- Novo Nordisk Foundation [NNF140C0011633]
- European Unions's Horizon Research and Innovation Program [633491]
- Danish Diabetes Academy - Novo Nordisk Foundation
- Novo Nordisk Fonden [NNF14OC0011633] Funding Source: researchfish
Small fibre neuropathies are a heterogeneous group of disorders affecting thinly myelinated Ad-fibres and unmyelinated C-fibres. Although multiple causes of small nerve fibre degeneration have been reported, including via genetic mutations, the cause of small fibre neuropathy remains unknown in up to 50% of cases. The typical clinical presentation of small fibre neuropathy is that of a symmetrical, length-dependent polyneuropathy associated with sensory or autonomic symptoms. More rarely, the clinical presentation is characterised by non-lengthdependent, focal, or multifocal symptoms. The diagnostic tests to identify small fibre neuropathy include skin biopsy, quantitative sensory, and autonomic testing. Additional tests, such as those measuring small fibre-related evoked potentials and corneal confocal microscopy, might contribute to a better understanding of these neuropathies. Biochemical markers can also help in screening patients for the presence of small fibre neuropathy and to assess disease progression.
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