4.2 Article

The Changing Epidemiology of Primary Liver Cancer

期刊

CURRENT EPIDEMIOLOGY REPORTS
卷 6, 期 2, 页码 104-111

出版社

SPRINGER HEIDELBERG
DOI: 10.1007/s40471-019-00188-3

关键词

Hepatocellular carcinoma; Hepatitis B virus; Hepatitis C virus; Aflatoxin; Non-alcohol fatty liver disease; obesity

资金

  1. National Institutes of Health Intramural Research Program, National Cancer Institute
  2. NATIONAL CANCER INSTITUTE [ZIACP010158] Funding Source: NIH RePORTER

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Purpose of ReviewIn prior decades, liver cancer was viewed as a neoplasm that almost exclusively arose among high-risk populations in low- and middle-income countries. Incidence rates in some high-risk populations, however, have been declining, while rates in low-risk populations have been increasing, reflecting changes in underlying etiology. In this review, we highlight the evolving epidemiology of liver cancer, focusing on recent research and advances.Recent FindingsEfforts to reduce or eliminate the risk associated with major risk factors such as hepatitis B virus (HBV), hepatitis C virus (HCV), and aflatoxin B-1 (AFB(1)) have met with some success. As opposed to these favorable trends, the joint epidemics of obesity and diabetes have begun to affect liver cancer rates around the world.SummaryWhile there has been progress in combating the effects of some risk factors, the increasing prevalence of others poses a major threat to attempts to tackle the rising incidence of liver cancer globally.

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