期刊
IEEE SOLID-STATE CIRCUITS LETTERS
卷 2, 期 6, 页码 41-44出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/LSSC.2019.2926644
关键词
Bio-sensing; chopping; correlated double sampling (CDS); personalized medicine; potentiostat
资金
- Defense Advanced Research Project Agency through the Mesodynamic Architectures Program [N66001-111-4111]
- Defense Advanced Research Project Agency through Dialysis Like Therapeutics Program [HR0011-15-C-0131]
- Maxim Integrated through Stanford's SystemX Fellow-MentorAdvisor Program
This letter presents a low-noise integrated potentiostat for affinity-free molecular detection in applications for personalized medicine. The affinity-free sensing technique uses a digital classifier to identify molecules through unique vibrational signatures. The sensing mechanism relies on coherent interference of electron wave functions at the interface between a nanoscale working electrode and a liquid electrolyte. Coherence at the sensing interface is enabled by low-noise feedback, which reduces the effective temperature of the electrons. The described three-channel potentiostat IC uses chopping and correlated double sampling to achieve an input-referred voltage noise of 12 nV/rt-Hz at 30 Hz and a current resolution of 1.8 pA(rms) with 0.5-s averaging time. Each channel consumes 5 mW and occupies 0.41 mm(2) in 65-nm CMOS.
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