期刊
LAB ON A CHIP
卷 17, 期 1, 页码 76-81出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6lc01217e
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类别
资金
- Studienstiftung des dt. Volkes
- Chiral Technologies Europe
- Deutsche Forschungsgemeinschaft (DFG) [FOR 2177]
We present a microfluidic system, seamlessly integrating microflow and microbatch synthesis with a HPLC/nano-ESI-MS functionality on a single glass chip. The microfluidic approach allows to efficiently steer and dispense sample streams down to the nanoliter-range for studying reactions in quasi real-time. In a proof-of-concept study, the system was applied to explore aminocatalyzed reactions, including asymmetric iminium-catalyzed Friedel-Crafts alkylations in microflow and micro confined reaction vessels.
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