期刊
LAB ON A CHIP
卷 17, 期 22, 页码 3841-3850出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7lc00857k
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资金
- Basic Science Research Program [2016R1A1A1A05005032]
- Center for Integrated Smart Sensor [CISS-2011-0031870]
- Future based Technology Development Program [2012-0009563]
- Ministry of Science, ICT & Future Planning
- Korean Health Technology RND project, Ministry of Health and Welfare Republic of Korea [HI13C1468, HI14C0559]
- Seoul Urban Data Science Laboratory Project (City of Seoul) [0660-20170004]
- BK21 plus program
- Korea Health Promotion Institute [HI14C0559020017] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
While the ion concentration polarization (ICP) phenomenon has been intensively researched for the last decade, a complete picture of ion and analyte distributions near nanoporous membranes is strongly desired, not only for fundamental nano-electrokinetic studies but also for the development of lab-on-a-chip applications. Since direct concentration measurements, using either time-consuming collection or micro-electrodes, are limited due to low throughput (< nL min(-1) in typical micro/nanofluidic device) and Faradaic reactions, respectively, we measured the concentration changes of prefilled solutions in individual reservoirs in this work. As a result, analytes larger than the size of nanopores were completely repelled by the ICP layer, 65% of cations were transported through the nanoporous membrane to sustain the ICP phenomenon, and the remaining anions were consumed by electrode reactions for electro-neutrality requirements. These combined effects would enable the perfect recovery of a target analyte and the removal of unnecessary salts simultaneously. Using this scenario, the novel concept of an ink recycler was also demonstrated in this work. We showed that 40% of unnecessary salt, which causes serious deterioration of inkjet heads, was removed, while the concentration of ink molecules was doubled in a single-step operation. This simultaneous desalting and molecular preconcentration mechanism would be a key operational strategy of various refinery/purification applications for drug discovery and the chemical industry, etc.
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