A new sensor based on glassy carbon electrode modified with Fe3O4@MCM-48-SO3H/multi-wall carbon nanotubes composite for simultaneous determination of norepinephrine and tyrosine in the presence of ascorbic acid

In this study, a novel method was developed to fabricate a glassy carbon electrode (GCE) modified by a composition of multi-walled carbon nanotubes (MWCNTs) and Fe3O4@MCM-48-SO3H nanoparticles (MWCNTs-Fe3O4@MCM-48-SO3H/GCE) as a sensitive anionic composite layer for simultaneous determination of norepinephrine (NE) and tyrosine (Tyr) in the presence of ascorbic acid (AA). Electrochemical behavior of the electrode was studied using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) and chronoamperometry (CA) techniques. Under the optimum conditions, the modified electrode provides a linear anodic peak versus NE concentrations in the range of 0.4-600M with a detection limit of 0.19M and Tyr concentrations in the range of 0.9-400M with a detection limit of 0.28M, respectively, using the differential pulse voltammetry method. The modified electrode has been successfully applied for the determination of NE and Tyr in real samples.