期刊
CHEMICAL SCIENCE
卷 10, 期 19, 页码 4994-4998出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8sc05167d
关键词
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资金
- National Institutes of Health NIGMS [R01-GM094541]
- NIGMS [R01-GM124319]
A boron and nitrogen containing unnatural analogue of tryptophan is synthesized through the functionalization of BN-indole. The spectroscopic properties of BN-tryptophan are reported with respect to the natural tryptophan, and the incorporation of BN-tryptophan into proteins expressed in E. coli using selective pressure incorporation is described. This work shows that a cellular system can recognize the unnatural, BN-containing tryptophan. More importantly, it presents the first example of an azaborine containing amino acid being incorporated into proteins.
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