期刊
CHEMICAL COMMUNICATIONS
卷 55, 期 39, 页码 5547-5550出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc01450k
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资金
- Natural Science Foundation of Jiangsu Province [BK20180447]
- Fundamental Research Funds for the Central Universities [30918011313]
The development of an iridium catalyzed enantioselective alpha-alkylation of azlactones has been described. The reaction provides rapid access to a wide range of enantio-enriched quaternary carbon center allylated 2,4-diaryloxazol-5(2H)-ones in excellent yields with high enantioselectivities. The transformation was achieved through a tandem allylic alkylation/aza-Cope rearrangement, affording the desired products under mild conditions. Ultimately, the resulting products could be readily converted into diverse enantio-enriched derivatives which highlight the importance of the methodology. Asymmetric allylic alkylation (AAA), which represents
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