期刊
CRYSTENGCOMM
卷 21, 期 18, 页码 2863-2874出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ce00124g
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资金
- Synthesis and Solid State Pharmaceutical Centre (SSPC) - Science Foundation Ireland (SFI)
- European Regional Development Fund [12/RC/2275]
- Bernal Institute at the University of Limerick
- Department of Chemical Sciences at the University of Limerick
The influence of temperature and solvent on the solid-liquid phase diagram of the 1 : 1 sulfamethazinesalicylic acid co-crystal has been investigated. Ternary phase diagrams of this co-crystal system have been constructed in three solvents: methanol, acetonitrile and a 7 : 3 (v/v) dimethylsulfoxide-methanol mixture, at three temperatures. The system exhibits congruent dissolution in acetonitrile and the co-crystal solubility has been determined by a gravimetric technique. The Gibbs energy of co-crystal formation from the respective solid components has been estimated from solubility data, together with the corresponding enthalpic and entropic component terms. The Gibbs energy of formation ranges from -5.7 to -7.7 kJ mol -1, with the stability increasing with temperature. In methanol and the DMSO-methanol mixture, the co-crystal dissolves incongruently. It is shown that the solubility ratio of the pure components cannot be used to predict with confidence whether the co-crystal will dissolve congruently or incongruently. The size of the region where the co-crystal is the only stable solid phase is inversely related to the pure component solubility ratio of salicylic acid and sulfamethazine.
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