期刊
CHEMICAL COMMUNICATIONS
卷 55, 期 34, 页码 4905-4908出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc01442j
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资金
- National Research Foundation of Korea (NRF) - Korean Government [2015R1C1A1A02037770, 2018R1D1A1A02085552]
- Ministry of Food and Drug Safety in 2019 [17162MFDS027]
- National Research Foundation of Korea [2018R1D1A1A02085552, 2015R1C1A1A02037770] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.
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