A proposal for standardized grading of chronic changes in native kidney biopsy specimens

Chronic changes represent an important component of native kidney biopsy evaluation and have a major bearing on predicting prognosis and guiding treatment. We propose here a uniform, semiquantitative approach to assessing such changes, which include glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis, and we report these findings as an overall chronicity grade. (C) 2017, International Society of Nephrology. Published by Elsevier Inc. All rights reserved.