期刊
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
卷 13, 期 2, 页码 933-938出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dsx.2018.12.022
关键词
Obesity; MDA; Non-enzymatic antioxidants; Trace elements; Macro-minerals; Bangladesh
Background and objective: Obesity is an emerging public health concern in Bangladesh. This study aimed to find the levels of the serum malondialdehyde (MDA), non-enzymatic antioxidants (vitamin A, C and E), trace elements (zinc and iron) and macro-minerals (calcium, potassium and sodium) in obesity and its action in disease advancement. Methods: Level of lipid peroxidation was estimated by measurement of the serum concentrations of malondialdehyde (MDA). Vitamin A and E concentration was found by RP-HPLC method and vitamin C was assessed for serum ascorbic acid by UV spectrophotometric method. Serum trace elements (Zn and Fe) and macro-minerals (Na, K and Ca) were estimated by Atomic Absorption Spectroscopy (AAS). Results: Our study observed significantly elevated concentrations of MDA (p < 0.001) and depleted concentrations of antioxidants (vitamin A, E and C) (p < 0.05) in the patient than control group. Analysis of serum trace elements (Zn and Fe) and macro-minerals (Na, K and Ca) and found that the mean values of Zn, Fe, Na, K and Ca were 0.39 +/- 0.02 and 0.43 +/- 0.03, 3284.81 +/- 34.51, 162.18 +/- 3.72, 44.62 +/- 2.13 mg/L for the patient and 0.91 +/- 0.13, 0.88 +/- 0.06, 2562.74 +/- 95.92, 243.58 +/- 8.97, 87.66 +/- 2.10 mg/L for the controls, consequently. There was a substantial difference in trace elements and macro-minerals between the patients and controls (p < 0.001). Conclusion: Our study proposes that increased serum concentrations of MDA and decreased nonenzymatic antioxidant and altered trace elements and macro-minerals are powerfully related with obesity. (c) 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
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