期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 47, 期 1-2, 页码 42-54出版社
KARGER
DOI: 10.1159/000495345
关键词
Neurodegenerative disease; Caregiver health; Patient behavioral symptoms; Patient cognitive symptoms; Voxel-based morphometry
资金
- National Institute on Aging [1R01AG041762-01A1, 2P01AG019724-11]
- National Institutes of Mental Health [5T32MH020006-20]
Background: Caregivers of patients with neurodegenerative diseases are at heightened risk for serious health problems, but health differences between individual caregivers abound. Aims: To determine whether atrophy in patient brains could be used to identify caregivers at heightened risk for health problems and which patient variables mediate this relationship. Methods: In 162 patient-caregiver dyads, we assessed patient atrophy using structural MRI, caregiver health, and patient behavior and cognitive symptoms. Results: Patient atrophy in the right insula and medial frontal gyrus was associated with worse caregiver health; this relationship was partially mediated by patient neuropsychiatric symptoms, and assessing atrophy in these regions improved predictions of poor caregiver health above and beyond patient behavioral symptoms. Conclusions: This study shows the value of patients' brain data in identifying caregivers at risk for becoming sick themselves. (c) 2019 S. Karger AG, Basel
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