期刊
THERANOSTICS
卷 9, 期 11, 页码 3280-3292出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.34412
关键词
intracellular protein delivery; supramolecular assemblies; protein therapeutics; endosomal escape; membrane fusion
资金
- NIH [GM008515, GM077173, EB022641]
- Research Corporation for Science Advancement (TREE award)
- Australian Cancer Council
- Australian-American Fulbright Association
- Cancer Council WA Top-Up Scholarship
Protein delivery into cells is a potentially transformative tool for treating undruggable targets in diseases associated with protein deficiencies or mutations. The vast majority of these targets are accessed via the cytosol, a challenging prospect for proteins with therapeutic and diagnostic relevance. In this review we will present promising non-viral approaches for intracellular and ultimately cytosolic delivery of proteins using nanocarriers. We will also discuss the mechanistic properties that govern the efficacy of nanocarrier-mediated protein delivery, applications of nanomaterials, and key challenges and opportunities in the use of nanocarriers for intracellular protein delivery.
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