期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 72, 期 7, 页码 922-928出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glw234
关键词
Frailty; Vulnerable Elders Survey-13; Balducci frailty criteria; Fried frailty criteria; Cancers
Background: Frailty increases the risk of adverse health outcomes and/or dying when exposed to a stressor, and routine frailty assessment is recommended to guide treatment decision. The Balducci frailty criteria (BFC) and Fried frailty criteria (FFC) are commonly used, but these are time consuming. Vulnerable Elders Survey-13 (VES-13) score of = 7, a simple and resource conserving function-based scoring system, may be used instead. This prospective study evaluates the performance of VES-13 in parallel with BFC and FFC, to identify frailty in elderly patients with early-stage cancer. Methods: Patients aged = 70 years with early-stage solid tumors were classified as frail/nonfrail based on BFC (= 1 criteria), FFC (= 3 criteria), and VES-13 (score = 7). All patients were assessed for functional decline and death. Results: We evaluated 185 patients. FFC had a 17% frailty rate, whereas BFC and VES-13 both had 25%, with poor concordance seen between the three geriatric tools. FFC (hazard ratio = 1.99, p =.003) and VES-13 (hazard ratio = 2.81, p <.001) strongly discriminated for functional decline, whereas BFC (hazard ratio = 3.29, p <.001) had the highest discriminatory rate for deaths. BFC and VES-13 remained prognostic for overall survival in multivariate analysis correcting for age, tumor type, stage, and systemic treatment. Conclusions: A VES-13 score of = 7 is a valuable discriminating tool for predicting functional decline or death and can be used as a frailtyscreening tool among older cancer patients in centers with limited resources to conduct a comprehensive geriatric assessment.
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