期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 73, 期 6, 页码 703-710出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glx164
关键词
Brain aging; Desaturases; Cytochrome p450 epoxygenase; Peroxisomal beta-oxidation; Inflammatory factors
资金
- Spanish Ministry of Economy and Competitiveness, Institute of Health Carlos III (FIS) [PI14/00757, PI14/00328]
- Autonomous Government of Catalonia [2014SGR69, 2014SGR168]
- FEDER funds from the European Union
Fatty acids are key components in the structural diversity of lipids and play a strategic role in the functional properties of lipids which determine the structural and functional integrity of neural cell membranes, the generation of lipid signaling mediators, and the chemical reactivity of acyl chains. The present study analyzes the profile of lipid fatty acid composition of membranes of human frontal cortex area 8 in individuals ranging from 40 to 90 years old. Different components involved in polyunsaturated fatty acid biosynthesis pathways, as well as adaptive defense mechanisms involved in the lipid-mediated modulation of inflammation, are also assessed. Our results show that the lipid profile in human frontal cortex is basically preserved through the adult life span to decay at advanced ages, which is accompanied by an adaptive proactive anti-inflammatory response possibly geared to ensuring cell survival and function.
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