期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 73, 期 5, 页码 571-578出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glx197
关键词
Mitochondria; COX deficiency; Exercise; Gut microbiota
资金
- European Union Seventh Framework Programme [Health-F2-2009-241762]
- Newcastle University Centre for Brain Ageing and Vitality - Biotechnology and Biological Sciences Research Council
- Engineering and Physical Sciences Research Council
- Economic and Social Research Council
- Medical Research Council [G0700718]
- UK National Institute for Health Research Biomedical Research Centre on Ageing and Age Related Diseases
- Diabetes UK
- ESRC [ES/K007688/1] Funding Source: UKRI
- MRC [MR/L016354/1, G0700718] Funding Source: UKRI
- Medical Research Council [G0700718, MR/L016354/1] Funding Source: researchfish
- NIHR Newcastle Biomedical Research Centre [BH111030] Funding Source: researchfish
Mitochondrial dysfunction is prevalent in the aging gastrointestinal tract. We investigated whether mitochondrial function in aging colonic crypts and exercise influences microbial gut communities in mice. Twelve PolgA(mut/mut) mice were randomly divided into a sedentary and exercise group at 4 months. Seven-aged matched PolgA(+/+) mice remained sedentary throughout. Stool samples were collected at 4, 7, and 11 months, and bacterial profiling was achieved through 16S rRNA sequencing profiling. Mitochondrial enzyme activity was assessed in colonic epithelial crypts at 11 months for PolgA(mut/mut) and PolgA(+/+) mice. Sedentary and exercised PolgA(mut/mut) mice had significantly higher levels of mitochondrial dysfunction than PolgA(+/+) mice (78%, 77%, and 1% of crypts, respectively). Bacterial profiles of sedentary PolgA(mut/mut) mice were significantly different from the sedentary PolgA(+/+) mice, with increases in Lactobacillus and Mycoplasma, and decreases in Alistipes, Odoribacter, Anaeroplasma, Rikenella, Parabacteroides, and Allobaculum in the PolgA(mut/mut) mice. Exercise did not have any impact upon gut mitochondrial dysfunction; however, exercise did increase gut microbiota diversity and significantly increased bacterial genera Mucispirillum and Desulfovibrio. Mitochondrial dysfunction is associated with changes in the gut microbiota. Endurance exercise moderated some of these changes, establishing that environmental factors can influence gut microbiota, despite mitochondrial dysfunction.
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