期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 73, 期 8, 页码 1070-1077出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glx203
关键词
Sarcopenia; diabetes; metabolism; physical activity
资金
- Canadian Diabetes Association [OG-3-14-4489-SP]
- Canadian Institutes for Health Research
- McMaster University Faculty of Science Interdisciplinary Research Fund
- Canada Research Chair
- Canadian Institutes of Health Research graduate scholarship
- Cisco Systems Canada, Inc.
- M.G. DeGroote Institute for Infectious Disease Research Summer Student Fellowship
Background: Physical inactivity impairs insulin sensitivity, which is exacerbated with aging. We examined the impact of 2 wk of acute inactivity and recovery on glycemic control, and integrated rates of muscle protein synthesis in older men and women. Methods: Twenty-two overweight, prediabetic older adults (12 men, 10 women, 69 +/- 4 y) undertook 7 d of habitual activity (baseline; BL), step reduction (SR; <1,000 steps.d(-1) for 14 d), followed by 14 d of recovery (RC). An oral glucose tolerance test was used to assess glycemic control and deuterated water ingestion to measure integrated rates of muscle protein synthesis. Results: Daily step count was reduced (all p < .05) from BL at SR (7362 +/- 3294 to 991 +/- 97) and returned to BL levels at RC (7117 +/- 3819). Homeostasis model assessment-insulin resistance increased from BL to SR and Matsuda insulin sensitivity index decreased and did not return to BL in RC. Glucose and insulin area under the curve were elevated from BL to SR and did not recover in RC. Integrated muscle protein synthesis was reduced during SR and did not return to BL in RC. Conclusions: Our findings demonstrate that 2 wk of SR leads to lowered rates of muscle protein synthesis and a worsening of glycemic control that unlike younger adults is not recovered during return to normal activity in overweight, prediabetic elderly humans.
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