期刊
EPILEPSY & BEHAVIOR CASE REPORTS
卷 11, 期 -, 页码 92-95出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ebcr.2019.01.008
关键词
Status epilepticus; Perampanel; MELAS
To our knowledge, there are no reports of status epilepticus (SE) associated with mitochondria! diseases and treated with perampanel (PER). We present three cases of patients with refractory SE associated with MELAS syndrome who responded favorably to PER. All cases were diagnosed as non-convulsive SE (focal without impairment of level of consciousness). After an initial treatment with other anti-seizure drugs, PER was added in all cases (8,16 and 12 mg) and cessation of SE was observed within the next 4-8 hours. All the cases involved a stroke-like lesion present on brain MRI. In our patients, PER was an effective option in SE associated with MELAS syndrome. (C) 2019 The Authors. Published by Elsevier Inc.
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