期刊
THERANOSTICS
卷 9, 期 11, 页码 3308-3340出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.33888
关键词
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资金
- Tier 1 [RG 5/18, RG110/16]
- NTU-JSPS JRP grant [M4082175.110]
- SSIJRI [203-A018003]
- Merlion program [M4082162.110, M408110000]
- MOE [2017-T2-2-110]
Nanotechnology-assisted spatiotemporal manipulation of biological events holds great promise in advancing the practice of precision medicine in healthcare systems. The progress in internal and/or external stimuli-responsive nanoplatforms for highly specific cellular regulations and theranostic controls offer potential clinical translations of the revolutionized nanomedicine. To successfully implement this new paradigm, the emerging light-responsive nanoregulators with unparalleled precise cell functions manipulation have gained intensive attention, providing UV-Vis light-triggered photocleavage or photoisomerization studies, as well as near-infrared (NIR) light-mediated deep-tissue applications for stimulating cellular signal cascades and treatment of mortal diseases. This review discusses current developments of light-activatable nanoplatforms for modulations of various cellular events including neuromodulations, stem cell monitoring, immunomanipulation, cancer therapy, and other biological target intervention. In summary, the propagation of light-controlled nanomedicine would place a bright prospect for future medicine.
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