期刊
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
卷 18, 期 4, 页码 324-333出版社
ZHEJIANG UNIV
DOI: 10.1631/jzus.B1600088
关键词
Vinegar; Antioxidant; Free radical scavenging property; Caenorhabditis elegans; Antioxidant enzyme; Reactive oxygen species (ROS); Apoptosis
类别
资金
- College of Food Science and Technology, Hunan Agricultural University, China
Xiangxi flavor vinegar (XV) is one of Hunan Province's traditional fermented vinegars. It is produced from herb, rice, and spring water with spontaneous liquid-state fermentation techniques. In this study, we investigated the antioxidant property of XV by analyzing its antioxidant compounds, its free radical scavenging property in vitro and in vivo, and its effects on antioxidant enzyme activity and apoptosis in Caenorhabditis elegans. The results showed that XV is rich in antioxidants. In particular, ligustrazine reached 6.431 mu g/ml. The in vitro 2,2-diphenyl-1-picrylhydrazyl free radical (DPPHaEuro cent), hydroxyl radical ((OH)-O-aEuro cent), and superoxide anion radical (O (2) (aEuro cent-) ) scavenging rates of XV were 95.85%, 97.22%, and 63.33%, respectively. The reactive oxygen species (ROS) content in XV-treated C. elegans decreased significantly (P < 0.01) compared to the control group. Glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT) activities were remarkably increased (P < 0.01) in C. elegans after XV treatment. In addition, XV could upregulate CED-9 protein expression and downregulate CED-3 protein expression in C. elegans. These results prove that XV is rich in antioxidants and scavenges radicals in vitro efficiently. XV inhibits apoptosis in C. elegans probably by scavenging ROS and increasing the activities of its antioxidant enzymes.
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