期刊
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
卷 60, 期 6, 页码 2208-2217出版社
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/iovs.18-26276
关键词
retinal vasculature; hypertension; epidemiology; population-based; aging
资金
- International Glaucoma Association (London, UK)
- UCLA Center for Eye Epidemiology (Los Angeles, CA, USA)
- Health Future Foundation
- Creighton University (Omaha, NE, USA)
- Texas Tech University Health Sciences Center (Lubbock, TX, USA)
- Pfizer, Inc. (New York, NY, USA)
- Merck & Co., Inc. (Whitehouse Station, NJ, USA)
- Pharmacia Hellas (Athens, Greece)
PURPOSE. To identify the factors associated with retinal vessel diameters in the population of the Thessaloniki Eye Study. METHODS. Cross-sectional population-based study (age >= 60 years). Subjects with glaucoma, late age-related macular degeneration, and diabetic retinopathy were excluded from the analyses. Retinal vessel diameters were measured using the IVAN software, and measurements were summarized to central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), and arteriole to venule ratio (AVR). RESULTS. The analysis included 1614 subjects. The hypertensive group showed lower values of CRAE (P = 0.033) and AVR (P = 0.0351) compared to the normal blood pressure (BP) group. On the contrary, the group having normal BP under antihypertensive treatment did not have different values compared to the normal BP group. Diastolic BP (per mm Hg) was negatively associated with CRAE (P < 0.0001) and AVR (P < 0.0001), while systolic BP (per mm Hg) was positively associated with CRAE (P = 0.001) and AVR (P = 0.0096). Other factors significantly associated included age, sex, alcohol, smoking, cardiovascular disease history, ophthalmic medication, weight, and IOP; differences were observed in a stratified analysis based on BP medication use. CONCLUSIONS. Our study confirms previous reports about the association of age and BP with vessel diameters. The negative correlation between BP and CRAE seems to be guided by the effect of diastolic BP as higher systolic BP is independently associated with higher values of CRAE. The association of BP status with retinal vessel diameters is determined by diastolic BP status in our population. Multiple other factors are also independently associated with retinal vessel diameters.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据