期刊
JOURNAL OF VIROLOGY
卷 91, 期 18, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00268-17
关键词
mass spectrometry; microscopy; organelle; proteomics; systems biology; virus-host interactions
类别
资金
- NIH [R01 GM114141, R01 HL127640]
- Mallinckrodt Scholar Award
- Dodds Fellowship
Viral replication in eukaryotes is a process inherently organized in both space and time. Viral components target subcellular organelles to access host machineries required for replication and spread. Diverse viruses are known to alter organelle shape, composition, function, and dynamics as part of their replication cycles. Here, we highlight recent advances in microscopy and proteomic methods that have helped and will continue to help define mechanisms used by viruses to exploit host proteome organization.
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