期刊
JOURNAL OF VIROLOGY
卷 91, 期 8, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00009-17
关键词
Zika virus; animal models; flavivirus; viral pathogenesis
类别
资金
- NIH [R01 AI08725, R01 AI073755, R01 AI104972, P01AI106695]
- Moderna
- Visterra
Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that now causes epidemics affecting millions of people on multiple continents. The virus has received global attention because of some of its unusual epidemiological and clinical features, including persistent infection in the male reproductive tract and sexual transmission, an ability to cross the placenta during pregnancy and infect the developing fetus to cause congenital malformations, and its association with Guillain-Barre syndrome in adults. This past year has witnessed an intensive effort by the global scientific community to understand the biology of ZIKV and to develop pathogenesis models for the rapid testing of possible countermeasures. Here, we review the recent advances in and utility and limitations of newly developed mouse and nonhuman primate models of ZIKV infection and pathogenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据