期刊
NEW JOURNAL OF CHEMISTRY
卷 43, 期 22, 页码 8811-8815出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9nj01826c
关键词
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资金
- Anhui Provincial Natural Science Foundation [1908085QB50]
- Doctoral Startup Foundation of Wannan Medical College [wYRCQD201715]
- Young Foundation of Wannan Medical College [WK201807]
- Natural Science Fund of Education Department of Anhui province [KJ2018A0257]
- National Natural Science Foundation of China [21602157]
- Swedish Government strategic faculty grant in material science (SFO, MATLIU) in Advanced Functional Materials (AFM) (VR) [5.1-2015-5959]
- Scientific Research Foundation for Academic and Technical Leader Reserve Candidate of Anhui Province [2016H086]
A novel water- soluble fluorescent probe L based on indole salts has been designed, synthesized and fully characterized. The systematic investigations demonstrated that probe L shows red emission and the fluorescence intensity is linear with the viscosity of the medium. Probe L is able to selectively accumulate in mitochondria within 1 min without any additional reagents for membrane permeabilization. It has been used to distinguish the viscosity differences between mitochondria in normal and nystatin- treated HeLa cells. In addition, due to the good photostability, probe L can be used to monitor the dynamics of mitochondria. These results support that probe L might provide a promising approach for the fluorescence detection of mitochondrial viscosity in living biological systems.
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