期刊
JOURNAL OF VETERINARY MEDICAL SCIENCE
卷 79, 期 2, 页码 -出版社
JAPAN SOC VET SCI
DOI: 10.1292/jvms.16-0451
关键词
chronic enteropathy; dog cytokines; epithelial cell-derived cytokines; food-responsive enteropathy; inflammatory bowel disease
资金
- Grants-in-Aid for Scientific Research [17K08099] Funding Source: KAKEN
It remains unclear whether epithelial cell-derived cytokines, including interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), contribute to development of canine chronic enteropathy (CE), which includes antibiotic-responsive enteropathy (ARE), food-responsive enteropathy (FRE) and inflammatory bowel disease (IBD). In the present study, we examined mRNA expression of il-25,il-33 and tslp in the duodenal and colonic mucosae of dogs with ARE, FRE and IBD. Real-time PCR analysis revealed that mRNA expression of il-33 was significantly lower in the duodenum in dogs with FRE than in healthy dogs. The results suggest that epithelial cell derived cytokines may not be an inducer of Th2-type immunity in the gut of dogs with CE, and decreased expression of IL-33 may be involved in induction of FRE. Further studies are required to clarify roles of epithelial cell-derived cytokines, especially IL-33, in the pathogenesis of canine CE.
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