期刊
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
卷 28, 期 6, 页码 804-810出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jvir.2017.01.018
关键词
-
资金
- University of Reims Champagne-Ardenne
- Unite Mixte de Recherche/Centre National de la Recherche Scientifique Matrice Extracellulaire et Dynamique Cellulaire [7369]
This study evaluated the midterm delivery of doxorubicin in liver specimens from patients (N = 4) with hepatocellular carcinoma treated with drug-eluting embolic (DEE) transarterial chemoembolization. The patients had surgical resection 57, 79, 80 and 105 days after doxorubicin DEE chemoembolization. Doxorubicin concentrations inside embolic particles and in surrounding tissues were assessed by infrared microspectroscopy and microspectrofluorimetry, respectively. Embolic particles still contained doxorubicin and provided sustained drug delivery Within targeted tissues 80 days after chemoermbolization. Doxorubicin was undetectable after 105 days. In addition, aggregation of embolic particles inside vessel lumina was associated with slower doxorubicin elution and higher tissue concentrations when the number of aggregated embolic partides increased.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据