期刊
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
卷 9, 期 5, 页码 188-195出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/2221-1691.258998
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Objective: To examine the effects of p-coumaric acid on ethanol-induced kidney injury in Swiss Wistar rats. Methods: Ethanol (25% v/v) was used to induce nephrotoxicity in rats. p-Coumaric acid was orally administered at 50, 100, or 200 mg/kg body weight. The levels of oxidative parameters were determined; pro-inflammatory biomarkers were analyzed by Western blotting and apoptotic protein was analyzed by immunohistochemistry. Results: Ethanol treated rats showed decreased levels of antioxidants and aberrant production of pro-inflammatory cytokines (IL-6, IL1 beta, TNF-alpha), NF-kappa B activation and imbalance of proand anti-apoptotic proteins (Bcl-2, Bax, caspase 3). Meanwhile, p-coumaric acid restored antioxidant levels and decreased the levels of inflammatory cytokines, NF-kappa B, and pro-apoptotic proteins and increased Bcl-2 expression. Conclusions: p-Coumaric acid ameliorates ethanol-induced kidney injury by restoring antioxidant production and suppressing cellular apoptosis and inhibiting NF-kappa B expression. p-Coumaric acid should be further investigated as a promising candidate for ethanol-induced kidney toxicity.
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