期刊
EARLY HUMAN DEVELOPMENT
卷 91, 期 11, 页码 637-642出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.earlhumdev.2015.08.009
关键词
Infant; Congenital bleeding disorders; Acquired bleeding disorders; Platelet disorders; Developmental haemostasis
The diagnosis of congenital and acquired bleeding disorders in infants requires an understanding of developmental haemostasis and the effect on laboratory testing. A systematic approach to bleeding in neonates will aid clinicians in the diagnosis and treatment, which may be caused by a wide variety of diseases. The clinical setting will help to direct the diagnostic pathway. This review will focus on the presentation and diagnosis of congenital and acquired bleeding disorders, including platelet disorders. Current research in this field is ongoing, including investigation into neonatal platelets and their different functionalities, platelet transfusion thresholds and how changes in coagulation factors may be linked to other homeostatic mechanisms. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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