期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 84, 期 11, 页码 7532-7540出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b00972
关键词
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资金
- National Key Research and Development Program of China [2018YFD0200100]
- National Natural Science Foundation of China [21732002, 21672117]
Herein, we report a mild protocol for metal-, photocatalyst-, and light-free Minisci C-H alkylation reactions of N-heteroarenes with alkyl oxalates derived from primary, secondary, and tertiary alcohols. The protocol uses environmentally benign persulfate as a stoichiometric oxidant and does not require high temperatures or large excesses of either of the substrates, making the procedure suitable for late-stage C-H alkylation of complex molecules. Notably, several pharmaceuticals and natural products could be functionalized or prepared with this protocol, thus demonstrating its utility.
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