4.5 Article

The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population

期刊

RESPIRATORY RESEARCH
卷 20, 期 -, 页码 -

出版社

BMC
DOI: 10.1186/s12931-019-1088-9

关键词

Asthma; Birth cohort; Longitudinal study; Development; Allergy; Environment; Children

资金

  1. HHS/NIH [5UG3OD023282]
  2. Columbia University [P01ES09600, R01 ES008977, P30ES09089, R01 ES013163, R827027]
  3. Tucson Children's Respiratory Study (TCRS) [NHLBI 132523]
  4. Infant Immune Study (IIS) [HL-56177]
  5. Childhood Origins of Asthma Study (COAST) [P01 HL070831, U10 HL064305, R01 HL061879]
  6. Wayne County Health, Environment, Allergy and Asthma Longitudinal Study (WHEALS) [R01 AI050681, R56 AI050681, R01 AI061774, R21 AI059415, K01 AI070606, R21 AI069271, R01 HL113010, R21 ES022321, P01 AI089473, R21 AI080066, R01 AI110450, R01 HD082147]
  7. Fund for Henry Ford Health System
  8. Childhood Allergy Study (CAS) [R01 AI024156, R03 HL067427, R01 AI051598]
  9. Blue Cross Foundation Johnson
  10. Fund for Henry Ford Hospital
  11. Microbes, Allergy, Asthma and Pets (MAAP) [P01 AI089473]
  12. Infant Susceptibility to Pulmonary Infections and Asthma following RSV Exposure (INSPIRE) [NIH/NIAID U19 AI 095227, NIH/NCATS UL1 TR 002243, NIH/NIAID K24 AI 077930, NIH/NHLBI R21 HD 087864, NIH/NHLBI X01 HL 134583]
  13. Wisconsin Infant Study Cohort (WISC) [U19 AI104317, NCATS UL1TR000427]
  14. Upper Midwest Agricultural Safety and Health Center (UMASH) [U54 OH010170]
  15. RTI International, Research Triangle Park, North Carolina, USA
  16. NIH [U24OD023382]
  17. Urban Environment and Childhood Asthma Study (URECA) [NO1-AI-25482, HHSN272200900052C, HHSN272201000052I, NCRR/NIH RR00052, M01RR00533, 1UL1RR025771, M01RR00071, 1UL1RR024156, UL1TR001079, 5UL1RR024992-02, NCATS/NIH UL1TR000040]
  18. Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS) [R01 ES11170, R01 ES019890]
  19. Epidemiology of Home Allergens and Asthma Study (EHAAS) [R01 AI035786]

向作者/读者索取更多资源

BackgroundSingle birth cohort studies have been the basis for many discoveries about early life risk factors for childhood asthma but are limited in scope by sample size and characteristics of the local environment and population. The Children's Respiratory and Environmental Workgroup (CREW) was established to integrate multiple established asthma birth cohorts and to investigate asthma phenotypes and associated causal pathways (endotypes), focusing on how they are influenced by interactions between genetics, lifestyle, and environmental exposures during the prenatal period and early childhood.Methods and resultsCREW is funded by the NIH Environmental influences on Child Health Outcomes (ECHO) program, and consists of 12 individual cohorts and three additional scientific centers. The CREW study population is diverse in terms of race, ethnicity, geographical distribution, and year of recruitment. We hypothesize that there are phenotypes in childhood asthma that differ based on clinical characteristics and underlying molecular mechanisms. Furthermore, we propose that asthma endotypes and their defining biomarkers can be identified based on personal and early life environmental risk factors. CREW has three phases: 1) to pool and harmonize existing data from each cohort, 2) to collect new data using standardized procedures, and 3) to enroll new families during the prenatal period to supplement and enrich extant data and enable unified systems approaches for identifying asthma phenotypes and endotypes.ConclusionsThe overall goal of CREW program is to develop a better understanding of how early life environmental exposures and host factors interact to promote the development of specific asthma endotypes.

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