期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 17, 期 21, 页码 5239-5243出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob00807a
关键词
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资金
- JSPS KAKENHI (Japan Society for the Promotion of Science (JSPS)) [17H05055, 17H05428]
- Naito Foundation
- Astellas Foundation for Research on Metabolic Disorders
- Grants-in-Aid for Scientific Research [17H05055, 17H05428] Funding Source: KAKEN
Polyketide synthase (PKS) gene-guided genome mining in a cricket-associated fungus, Penicillium soppi, revealed a cryptic biosynthetic gene cluster that contained a highly reducing PKS (HR-PKS), a type III PKS, and a P450 gene. Heterologous expression of the cluster in Aspergillus oryzae led to the isolation of novel alkylresorcinols with a unique Z,E,Z-triene motif. This study displays an unusual biosynthetic mechanism of an HR-PKS and a new releasing mechanism via a type III PKS in fungi.
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