Metabolic reprogramming and tumor immunity under hypoxic microenvironment

Cancer cells are frequently surrounded by hypoxic microenvironment and, to survive, they have evolved multiple adaptations. One of the hallmark adaptations for cancer cells is the rewired metabolism, in which hypoxia plays important roles. Besides rewired metabolism in cancer cells, much progresses has emerged in hypoxia-regulated immune cells and immune responses as well. Here, we will review the recent progress in the field of rewired cancer metabolism and tumor immunity regulated by hypoxic microenvironment.