4.6 Review

Molecularly imprinted polymer-based electrochemical sensors for biopolymers

期刊

CURRENT OPINION IN ELECTROCHEMISTRY
卷 14, 期 -, 页码 53-59

出版社

ELSEVIER
DOI: 10.1016/j.coelec.2018.12.005

关键词

Electropolymerization; Direct electron transfer; Redox marker; Epitope imprinting; Biomarker

资金

  1. Deutsche Forschungsgemeinschaft (DFG, Germany) [EXC 314]
  2. ERA-Chemistry 2014 [61133]
  3. NKFIH OTKA (Hungary) [NN117637]
  4. BME-Nanotechnology (Hungary) FIKP grant of EMMI (BME FIKP-NAT)

向作者/读者索取更多资源

Electrochemical synthesis and signal generation dominate among the almost 1200 articles published annually on protein-imprinted polymers. Such polymers can be easily prepared directly on the electrode surface, and the polymer thickness can be precisely adjusted to the size of the target to enable its free exchange. In this architecture, the molecularly imprinted polymer (MIP) layer represents only one 'separation plate'; thus, the selectivity does not reach the values of 'bulk' measurements. The binding of target proteins can be detected straightforwardly by their modulating effect on the diffusional permeability of a redox marker through the thin MIP films. However, this generates an 'overall apparent' signal, which may include nonspecific interactions in the polymer layer and at the electrode surface. Certain targets, such as enzymes or redox active proteins, enables a more specific direct quantification of their binding to MIPs by in situ determination of the enzyme activity or direct electron transfer, respectively.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据