4.7 Article

Nanofocused synchrotron X-ray absorption studies of the intracellular redox state of an organometallic complex in cancer cells

期刊

CHEMICAL COMMUNICATIONS
卷 55, 期 49, 页码 7065-7068

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc01675a

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资金

  1. CRUK/EPSRC [C53561/A19933]
  2. EPSRC [EP/F034210/1]
  3. Wellcome Trust [107691/Z/15/Z]
  4. EPSRC [EP/F034210/1] Funding Source: UKRI
  5. Wellcome Trust [107691/Z/15/Z] Funding Source: Wellcome Trust

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Synchrotron nanoprobe X-ray absorption (XAS) studies of a potent organo-osmium arene anticancer complex in ovarian cancer cells at subcellular resolution allow detection and quantification of both Os-II and Os-III species, which are distributed heterogeneously in different areas of the cells.

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