期刊
JOURNAL OF TRANSLATIONAL MEDICINE
卷 15, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12967-017-1218-4
关键词
Genetic toxicology; Genotoxicity; In-vivo testing; The Ames assay; Comet assay; Germ cells; Stem cells; Epigenetics
资金
- National Natural Science Foundation of China [81472672]
Genotoxicity refers to the ability of harmful substances to damage genetic information in cells. Being exposed to chemical and biological agents can result in genomic instabilities and/or epigenetic alterations, which translate into a variety of diseases, cancer included. This concise review discusses, from both a genetic and epigenetic point of view, the current detection methods of different agents' genotoxicity, along with their basic and clinical relation to human cancer, chemotherapy, germ cells and stem cells.
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