Glycan-modified interfaces in biosensing: an electrochemical approach

Glycans (complex carbohydrates) attached to various interfacial layers represent a simple but functional model of a cellular surface, which is covered densely by glycans. In this review, we discuss interactions of surface-confined glycans with various glycan-binding proteins, viruses, or pathogenic bacteria. Such glycan receptive interfaces can be applied for bio-sensing of these analytes. In this review, we focus on the application of glycan interfaces for label-free electrochemical biosensing.