期刊
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
卷 41, 期 -, 页码 16-22出版社
ELSEVIER GMBH
DOI: 10.1016/j.jtemb.2017.01.006
关键词
Desferrioxamine; Aluminum; Gallium; Caffeine; Trojan horse
资金
- National Council for Scientific Development (National Council for Scientific and Technological Development)
- Sao Paulo Research Foundation (FAPESP) [2011/50318-1, 2016/03709-9]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [11/50318-1] Funding Source: FAPESP
Iron acquisition by bacteria and fungi involves in several cases the promiscuous usage of siderophores. Thus, antibiotic resistance from these microorganisms can be circumvented through a strategy of loading toxic metals into siderophores (Trojan Horse Effect). Desferrioxamine (dfo) and its cell-permeant derivative desferrioxamine-caffeine (dfcaf) were complexed with aluminum or gallium for this purpose. The complexes Me(dfo) and Me(dfcaf) (Me = Al3+ and Ga3+) were synthesized and characterized by mass spectroscopy and cyclic voltammetry. Their relative stabilities were studied through competitive equilibria with fluorescent probes calcein, fluorescein-desferrioxamine and 8-hydroxyquinoline. Me(dfo) and Me(dfcaf) were consistently more toxic than free Me3+ against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans, demonstrating the Trojan Horse Effect. Wide spectrum antimicrobial action can be obtained by loading non-essential or toxic metal ions to microbes via a convenient siderophore carrier. (C) 2017 Elsevier GmbH. All rights reserved.
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