期刊
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
卷 12, 期 4, 页码 890-896出版社
WILEY
DOI: 10.1002/term.2445
关键词
bioactive molecule; chitosan; hydrogel; radiation; repair; skin
类别
资金
- National R&D Program through the Korea Institute of Radiological and Medical Sciences (KIRAMS) - Ministry of Science, ICT & Future Planning [1711045557, 1711045538, 1711045554/50531-2017]
- Technology Innovation Program - Ministry of Trade, Industry and Energy (MOTIE, Korea) [10053595]
Clinical irradiation therapy for cancer could increase the risk of localized wound complications. This study was conducted to evaluate the potential use of a chitosan microparticle-pluronic F127 (CSMP-PF) hydrogel complex containing bioactive molecules, substance P and transforming growth factor-beta 1, to regeneratively repair skin damaged by local ionizing radiation (IR). The BALB/c/bkl mice were locally irradiated to their limbs with a single 40 Gy dose of Co-60 gamma rays to induce a skin injury. The morphological characteristics of the chitosan microparticles were analysed by scanning electron microscopy. The amounts of bioactive molecules taken up and released by the CSMP-PF hydrogel complex were measured. Haematoxylin and eosin staining of IR-damaged skin showed acanthosis and hyperkeratosis in the epidermis; and damage to hair follicles/skin appendages and adipose tissue, as well as panniculus carnosus, in the dermis. Injection of the CSMP-PF hydrogel complex into IR-damaged skin resulted in skin repair, suggesting that the complex has potential for use in the regenerative repair of IR-damaged skin.
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